Product Details
Chemical Structure : GS-5734
CAS No.: 1809249-37-3
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GS-5734 (GS 5734;GS5734;Remdesivir)
Catalog No.: URK-V1174Â Â Only Used For Lab.
GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays.
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Stock
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Quantity
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5mg
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25mg
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100mg
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250mg
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1g
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Biological Activity
GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays.
GS-5734 (Remdesivir) suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers.
GS-5734 (Remdesivir) is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.
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Physicochemical Properties
M.Wt
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601.597
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Formula
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C28H36N5O8P
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CAS No.
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1809249-37-3
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Storage
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Solide Powder
-20 °C 3years;
4°C 2years
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In Solvent
-80°C 6 Months
-20°C 1 Months
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Solubility
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10 mM in DMSO
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Chemical Name
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2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-b]pyridazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
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References
1. Warren TK, et al. Nature. 2016 Mar 17;531(7594):381-5.
2. Jacobs M, et al. Lancet. 2016 Jul 30;388(10043):498-503.
3. Siegel D, et al. J Med Chem. 2017 Mar 9;60(5):1648-1661.
Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!
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